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RAGE Mediates a Novel Proinflammatory Axis: A Central Cell Surface Receptor for S100/Calgranulin Polypeptides

Research from the journal Experimental Gerontology describes a theory where deteriorating melatonin rhythms cause other circadian rhythms to weaken and desynchronize, contributing significantly to the aging process itself and rendering the body more susceptible to age-related diseases

The trial has been prospectively registered on australianclinicaltrials.gov.au (ACTRN12620000506998) and will be conducted within the estimand framework for the design and analysis of clinical trials

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